A Two-Dimensional Model of Blood Plasma Flow with Oxygen Transport and Blood Cell Membrane Deformation
نویسندگان
چکیده
Sickle cell disease (SCD) is a genetic disorder that alters the red blood cell (RBC) structure and function such that hemoglobin (Hb) cannot effectively bind and release oxygen. Our novel 2-D computational model represents a fast, time efficient method developed to analyze flow dynamics, O2 diffusion, and cell deformation in the microcirculation. A finite difference, Crank-Nicholson scheme is used to compute the flow and O2 concentration, and the level set computational method is used to advect the RBC membrane on a staggered grid. Simulation data implicates a few parameters to be significant in the perturbation of the blood flow and O2 concentration profiles.
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